A group of scientists argue, in a review published in Fluids and Barriers of the CNS earlier this year, that it’s time to adopt a more apt metaphor. Jan Pieter Konsman and Jerome Badaut of the ...

Scientists are honing transferrin receptors to whisk bulky, anti-Aβ antibodies throughout the brain without setting off ARIA and anemia. By halving the effector function of their antibody transport ...

Frontotemporal dementia (FTD) often strikes our most human traits, such as the ability to speak and to interact on social and emotional levels. Now, research led by Lorenzo Pasquini and William Seeley ...

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Two of the groups reported that cultured human oligodendrocytes make as much or more Aβ than do neurons, and that ...

Do you know a conference you think we should list? Let us know by sending us an email with the details to conferences@alzforum.org.

About two-thirds of people with Alzheimer’s disease are women, yet due to the challenges in studying X chromosomes, a genetic ...

PSEN1 encodes presenilin-1, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. More than 300 mutations in PSEN1 have been reported and mutations in PSEN1 are the most ...

Long before carriers of autosomal-dominant AD mutations notice the first hints of memory loss, changes in their brains are ...

Dozens of rodents have been generated that model various aspects of ALS, like motor impairment or degeneration of motor neurons. No model recapitulates the human disease perfectly. By organizing ...

The National Alzheimer’s Coordinating Center unites the collections of the neuropathology cores at 27 NIA-funded AD Research Centers into a single database. It contains records on 13,000 brains, 3,000 ...